{"id":6755,"date":"2025-12-02T18:34:34","date_gmt":"2025-12-02T18:34:34","guid":{"rendered":"https:\/\/mehnatt.com\/?p=6755"},"modified":"2025-12-02T18:38:54","modified_gmt":"2025-12-02T18:38:54","slug":"mcqs-on-current-affairs-01-12-2025","status":"publish","type":"post","link":"https:\/\/mehnatt.com\/?p=6755","title":{"rendered":"MCQs on Current Affairs 01.12.2025"},"content":{"rendered":"\n<h3 class=\"wp-block-heading\">Q1. Which of the following best explains why both PANC-1 and CAPAN-2 pancreatic cancer cell lines show increased migration under hypoxia?<\/h3>\n\n\n\n<ol class=\"wp-block-list\">\n<li style=\"font-size:17px\">Hypoxia uniformly decreases membrane stiffness in all cancer cells<\/li>\n\n\n\n<li style=\"font-size:17px\">Hypoxia triggers lipid and cytoskeletal adjustments that maintain membrane malleability<\/li>\n\n\n\n<li style=\"font-size:17px\">Hypoxia increases the number of mitochondria, giving cells more energy to move<\/li>\n\n\n\n<li style=\"font-size:17px\">Hypoxia reduces all stiffening lipids in the plasma membrane<\/li>\n<\/ol>\n\n\n\n<button class=\"acc\">View Answer<\/button>\n<div class=\"pnl\">\n  <p style=\"padding-top:5px;color:#27302a;font-size:1.2rem;\"><b>Correct Option:<\/b> 2. Hypoxia triggers lipid and cytoskeletal adjustments that maintain membrane malleability. <br\/>\n<strong>Explanation:<\/strong><br\/> \u2022 The studies showed that PANC-1 and CAPAN-2 respond differently at the mechanical level \u2014 PANC-1 becomes less stiff, while CAPAN-2 becomes more stiff.<br\/>\n\u2022 Yet, both maintain or regain membrane malleability needed for migration by adjusting lipid composition and membrane trafficking.<br\/>\n\u2022 This ability to re-balance membrane properties under hypoxia leads to enhanced migration.<br\/>\n\u2022 Options A and D are incorrect because hypoxia does not uniformly reduce stiffness or stiffening lipids; in CAPAN-2 stiffening lipids even increase.<br\/>\n\u2022 Option C is not supported by the research.\n\n\n<\/p> <\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\">Q2. What was the major unexpected observation when researchers first examined the membrane properties of PANC-1 cells under hypoxia?<\/h3>\n\n\n\n<ol class=\"wp-block-list\">\n<li style=\"font-size:17px\">The membrane completely lost its lipid content<\/li>\n\n\n\n<li style=\"font-size:17px\">The broad physical properties of the plasma membrane did not change significantly<\/li>\n\n\n\n<li style=\"font-size:17px\">The membrane became fully rigid despite increased migration<\/li>\n\n\n\n<li style=\"font-size:17px\">The cells stopped migrating<\/li>\n<\/ol>\n\n\n\n<button class=\"acc\">View Answer<\/button>\n<div class=\"pnl\">\n  <p style=\"padding-top:5px;color:#27302a;font-size:1.2rem;\"><b>Correct Option:<\/b> 2. The broad physical properties of the plasma membrane did not change significantly. <br\/>\n<strong>Explanation:<\/strong><br\/> \u2022 The researchers expected hypoxia-induced migration to correlate directly with major changes in membrane order or fluidity.<br\/>\n\u2022 Surprisingly, these broad membrane properties did not change much, leading them to analyze the lipidome composition instead.<br\/>\n\u2022 This deeper analysis revealed shifts in lipid types and trafficking, not large-scale membrane physical changes, were driving migration.<br\/>\n\u2022 Options A, C, and D are incorrect because:<br\/>\n\u2013 The membrane did not lose lipids (A).<br\/>\n\u2013 It did not become fully rigid (C).<br\/>\n\u2013 The cells migrated more, not less (D).\n\n\n<\/p> <\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n","protected":false},"excerpt":{"rendered":"<p>Q1. Which of the following best explains why both PANC-1 and CAPAN-2 pancreatic cancer cell lines show increased migration under hypoxia? View Answer Correct Option: 2. Hypoxia triggers lipid and cytoskeletal adjustments that maintain membrane malleability. Explanation: \u2022 The studies showed that PANC-1 and CAPAN-2 respond differently at the mechanical level \u2014 PANC-1 becomes less [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[18],"tags":[222,608,21,22,31,607,221,20],"class_list":["post-6755","post","type-post","status-publish","format-standard","hentry","category-current-affairs","tag-bank-exams","tag-capan-2","tag-competitive-exams","tag-current-affairs","tag-mcq","tag-panc-1","tag-rrb-exams","tag-ssc-cgl"],"_links":{"self":[{"href":"https:\/\/mehnatt.com\/index.php?rest_route=\/wp\/v2\/posts\/6755","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mehnatt.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mehnatt.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mehnatt.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/mehnatt.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=6755"}],"version-history":[{"count":5,"href":"https:\/\/mehnatt.com\/index.php?rest_route=\/wp\/v2\/posts\/6755\/revisions"}],"predecessor-version":[{"id":6789,"href":"https:\/\/mehnatt.com\/index.php?rest_route=\/wp\/v2\/posts\/6755\/revisions\/6789"}],"wp:attachment":[{"href":"https:\/\/mehnatt.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=6755"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mehnatt.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=6755"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mehnatt.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=6755"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}